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UTICAJ ETARSKOG ULJA RUZMARINA PRIMENJENOG per os NA FARMAKODINAMSKA I FARMAKINETSKA SVOJSTVA PARACETAMOLA

ISSN 2232-755X
UDC:615.276.03:582.282.123

Isidora Milanović, Aleksandar Rašković, Saša Vukmirović, Nebojša Stilinović, Momir Mikov,

Uvod: Etarsko ulje ruzmarina se koristi za tretman dispepsije, blagih spazama gastrointestinalnog trakta; spolja kao analgetik za lečenje blažih mijalgija i bolova u zglobovima, i za poboljšanje periferne cirkulacije. Stoga je važno ispitati analgetski potencijal etarskog ulja ruzmarina i njegov uticaj na farmakokinetske i farmakodinamske osobine drugih analgetika, odnosno u našem slučaju paracetamola. Metodologija: Etarsko ulje ruzmarina je primenjivano oralno (10 i 20 mg/kg TM) tokom sedam dana za potrebe farmakodinamskih testova. Pacovi su tretirani etarskim uljem ruzmarina per os sedam dana (5 i 10 mg/kg TM). Na njima je ispitivan uticaj etarskog ulja ruzmarina na farmakokinetske osobine paracetamola (primenjenog sedmog dana per os ili intravenski). Farmakokinetski parametri su ispitivani u uzorcima krvi pacova dobijenim iz repne vene HPLC metodom. Rezultati: Etarsko ulje ruzmarina je pokazalo analgetski efekat. Etarsko ulje ruzmarina je pojačalo analgetski efekat paracetamola i ne utiče na biološku raspoloživost paracetamola. Zaključak: Biljni lekovi mogu uticati na farmakodinamiku i farmakokinetiku klasičnih lekova, a time i na bezbednost primene tih lekova u humanoj populaciji.

Ključne riječi: Ruzmarin, interakcije lekovi-lekovite biiljke,

THE INFLUENCE OF ROSEMARY ESSENTIAL OIL APPLIED PER OS ON THE PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES OF PARACETAMOL

Isidora Milanović, Aleksandar Rašković, Saša Vukmirović, Nebojša Stilinović, Momir Mikov,

Introduction: Rosemary essential oil can be used for treating dyspepsia, mild spasmodic disorders of the gastrointestinal tract, externally as analgetic in muscular and articular pain and minor peripheral circulatory disorders. It is important to explore its analgesic potential and its influence on the pharmacodynamic and pharmacokinetic properties of paracetamol. Methodology: Rosemary essential oil was applied to mice orally (doses: 10 and 20 mg/kg b.w.) for pharmacodynamic tests for seven days. Rats treated with rosemary essential oil for seven days orally (5 and 10 mg/kg b.w.) were used for the examination of the influence of essential oil on the pharmacokinetic properties of paracetamol (applied on the 7th day p.o. or i.v.). Pharmacokinetic parameters were analyzed in blood samples obtained from rats tail veins, with the HPLC method. Results: The essential oil of rosemary shows analgetic properties. The rosemary essential oil increases pharmacological effects of paracetamol and does not change paracetamol bioavailability. Conclusion: The herbal drugs could change the pharmacodynamic and the pharmacokinetic properties of classical drugs and they could also change the safety of classical drugs use in human population.

Key words: Rosemary, Herb-Drugs Interactions, Paracetamol